Emedinews:Tat Tvam Asi:Cryoprecipitate:

Tat Tvam Asi……..and the Life Continues…..
(Dr N K Bhatia, Medical Director, Mission Jan Jagriti Blood Bank)

Cryoprecipitate:

Definition: Cryoprecipitate are precipitated proteins of plasma rich in factor VIII and fibrinogen obtained from a single unit of fresh frozen plasma.

Volume: 10 - 20 ml

Storage: At -30° C or colder

Shelf life: 1 year

Note: It should be thawed in blood bank in thawing bath between 30° C to 37° C before use. Once thawed, the cryoprecipitate should be transfused immediately but in any case not later than 6 hours.

Indications:

• As an alternative to factor VIII concentrate in the treatment of inherited deficiencies of:
• Von Willebrand factor ( Von Willebrand disease)
• Factor VIII (hemophilia A)
• Factor XIII
• As a source of fibrinogen in acquired coagulopathies e.g. disseminated intravascular coagulation (DIC)

Dosage: 2 units/10 kg wt. One bag contains more than 80 units of factor VIII and more than 150 mg of fibrinogen.

Dose of factor VIII (Cryoprecipitate) depends upon the nature of bleeding episode and severity of factor VIII deficiency. Each unit of factor VIII per kg raises plasma factor VIII by 2%.

Administration:

1.      No compatibility testing required

2.      After thawing, infuse as soon as possible through a standard blood transfusion set

3.      Must be transfused immediately or within 4 hours of thawing